HEMATOPOIESIS AND STEM CELLS Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice
نویسندگان
چکیده
1Inserm Unité Mixte de Recherche (UMR) S996, Université Paris-Sud, Laboratory of Excellence in Research on Medication and Innovative Therapeutics, Clamart, France; 2Inserm U819, Paris, France; 3Laboratoire de Pathogénie Virale, Institut Pasteur, Paris, France; 4Plateforme d’Immunomonitorage, Institut Paris-Sud d’Innovation Thérapeutique, Clamart, France; 5Laboratoire d’Hématologie, Assistance Publique–Hôpitaux de Paris (AP-HP), Hôpital Robert Debré, Paris, France; 6Laboratoire d’Innovation Thérapeutique, UMR 7200, Centre National de la Recherche Scientifique/Université de Strasbourg, Faculté de Pharmacie, Illkirch, France; 7Histopathologie Humaine et Modèles Animaux, Institut Pasteur, Paris, France; and 8Service de Microbiologie-Immunologie Biologique, AP-HP, Hôpital Antoine-Béclère, Clamart, France
منابع مشابه
Lymphoid differentiation of hematopoietic stem cells requires efficient Cxcr4 desensitization
The CXCL12/CXCR4 signaling exerts a dominant role in promoting hematopoietic stem and progenitor cell (HSPC) retention and quiescence in bone marrow. Gain-of-function CXCR4 mutations that affect homologous desensitization of the receptor have been reported in the WHIM Syndrome (WS), a rare immunodeficiency characterized by lymphopenia. The mechanisms underpinning this remain obscure. Using a mo...
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Natural killer (NK) cells are granular lymphocytes that are generated from hematopoietic stem cells and play vital roles in the innate immune response against tumors and viral infection. Generation of NK cells is known to require several cytokines, including interleukin-15 (IL-15) and Fms-like tyrosine kinase 3 ligand, but not IL-2 or IL-7. Here we investigated the in vivo role of CXC chemokine...
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clonal antibody (mAb) (12G5 clone, Pharmingen, San Diego, CA) and were costained with fluorescein isothyocyanate (FITC)conjugated mAb directed against CD34, CD33, CD61, CD105, and glycophorin-A.8 CD341 cells mobilized by chemotherapy and G-CSF homogeneously expressed CD33, CD13, and HLA-DR antigens, thus confirming previous observations (Figure, A).5 CXCR4 was expressed on the majority of circu...
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